Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Sodium fluoride (7681-49-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020630

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Sodium fluoride (7681-49-4).
Rodent Cytogenetics
CA
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Sodium fluoride (7681-49-4).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Sodium fluoride (7681-49-4).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Sodium fluoride (7681-49-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Sodium fluoride (7681-49-4).
Bacterial Mutagenicity
View
  • Negative

Citation Information

NTP. Sodium fluoride (7681-49-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-393 Toxicology and Carcinogenesis Studies of Sodium Fluoride (CASRN 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking WaterStudies)
Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website http://ntp.niehs.nih.gov/go/16389)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Final Report on the Developmental Toxicity of Sodium Fluoride in Sprague-Dawley (CD) Rats
Final Report on the Developmental Toxicity of Sodium Fluoride in Sprague-Dawley (CD) Rats
Final Report on the Developmental Toxicity of Sodium Fluoride in New Zealand White Rabbits
Final Report on the Developmental Toxicity of Sodium Fluoride in New Zealand White Rabbits
Caspary, W., Myhr, B., Bowers, L., McGregor, D., Riach, C., and Brown, A. Mutagenic activity of fluorides in mouse lymphoma cells. Mutation Res. Vol. 187 (1987) 165-180

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity (C55221C) of Sodium Fluoride (7681-49-4) in F344/N Rats Exposed via Dosed Water
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55221B) of Sodium Fluoride (7681-49-4) in F344/N Rats Exposed via Dosed Water
Pathology Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C55221B) of Sodium Fluoride (7681-49-4) in B6C3F1 Mice Exposed via Dosed Water
Pathology Tables
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of Sodium Fluoride (7681-49-4) in Micronucleus Study A12928 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Sodium Fluoride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 687373
Summary Data

Other NTP Studies

Prenatal Developmental Toxicity Study (TER91022) of Sodium Fluoride (7681-49-4) in Sprague-Dawley Rats Exposed via Dosed Water
Individual and Summary Data
Prenatal Developmental Toxicity Study (TER91033) of Sodium Fluoride (7681-49-4) in New Zealand White Rabbits Exposed via Dosed Water
Individual and Summary Data

Other Studies

DTT Data Collections