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Sodium fluoride (7681-49-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2020630


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Sodium fluoride (7681-49-4).
Rodent Cytogenetics
CA
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Sodium fluoride (7681-49-4).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Sodium fluoride (7681-49-4).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Sodium fluoride (7681-49-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Sodium fluoride (7681-49-4).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Sodium fluoride (7681-49-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-393 Toxicology and Carcinogenesis Studies of Sodium Fluoride (CASRN 7681-49-4) in F344/N Rats and B6C3F1 Mice (Drinking WaterStudies)
Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website http://ntp.niehs.nih.gov/go/16389)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Final Report on the Developmental Toxicity of Sodium Fluoride in Sprague-Dawley (CD) Rats
Final Report on the Developmental Toxicity of Sodium Fluoride in Sprague-Dawley (CD) Rats
Final Report on the Developmental Toxicity of Sodium Fluoride in New Zealand White Rabbits
Final Report on the Developmental Toxicity of Sodium Fluoride in New Zealand White Rabbits
Caspary, W., Myhr, B., Bowers, L., McGregor, D., Riach, C., and Brown, A. Mutagenic activity of fluorides in mouse lymphoma cells. Mutation Res. Vol. 187 (1987) 165-180

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity (C55221C) of Sodium Fluoride (7681-49-4) in F344/N Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C55221B) of Sodium Fluoride (7681-49-4) in F344/N Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C55221B) of Sodium Fluoride (7681-49-4) in B6C3F1 Mice Exposed via Dosed Water

Other NTP Studies


Prenatal Developmental Toxicity Study (TER91022) of Sodium Fluoride (7681-49-4) in Sprague-Dawley Rats Exposed via Dosed Water
Prenatal Developmental Toxicity Study (TER91033) of Sodium Fluoride (7681-49-4) in New Zealand White Rabbits Exposed via Dosed Water