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1,2-Dichloropropane (78-87-5)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020448

Study Results

Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Male, Rats
View
  • Equivocal Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Some Evidence, Male, Mice
View
  • Some Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 1,2-Dichloropropane (78-87-5).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,2-Dichloropropane (78-87-5).
Mammalian Cell Mutagenicity
View
  • Positive
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,2-Dichloropropane (78-87-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,2-Dichloropropane (78-87-5).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,2-Dichloropropane (78-87-5).
Bacterial Mutagenicity
View
  • Weakly Positive
View
  • Weakly Positive

Citation Information

NTP. 1,2-Dichloropropane (78-87-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Related Links

Publications

TR-263 Toxicology and Carcinogenesis Studies of 1,2-Dichloropropane (Propylene Dichloride) (CASRN 78-87-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloropropane (Propylene Dichloride) (78-87-5) in Male F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloropropane (Propylene Dichloride) (78-87-5) in Female F344 Rats Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloropropane (Propylene Dichloride) (78-87-5) in Male B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,2-Dichloropropane (Propylene Dichloride) (78-87-5) in Female B6C3F1 Mice Exposed via Gavage
Individual Animal Data
Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of 1,2-Dichloropropane (Propylene Dichloride) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 566847
Summary Data
Genetic Toxicity Evaluation of 1,2-Dichloropropane (Propylene Dichloride) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 627177
Summary Data

NTP Data Collections