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Milk thistle extract (84604-20-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Milk thistle extract (84604-20-6).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Milk thistle extract (84604-20-6).
Bacterial Mutagenicity
View
  • Positive
View
  • Positive
View
  • Negative
View
  • Negative
View
  • Positive
View
  • Negative

Citation Information


NTP. Milk thistle extract (84604-20-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-565 Toxicology and Carcinogenesis Studies of Milk Thistle Extract (CASRN 84604-20-6) in F344/N Rats and B6C3F1 Mice (Feed studies)
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C20008) of Milk Thistle Extract (84604-20-6) in F344 Rats Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C20008) of Milk Thistle Extract (84604-20-6) in B6C3F1 Mice Exposed via Dosed Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C20008) of Milk Thistle Extract (84604-20-6) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C20008) of Milk Thistle Extract (84604-20-6) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C20008) of Milk Thistle Extract (84604-20-6) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C20008) of Milk Thistle Extract (84604-20-6) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Milk Thistle Extract (84604-20-6) in Micronucleus Study A73501 in B6C3F1 Mice
Genetic Toxicity Evaluation of Milk Thistle Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A21904
Summary Data
Genetic Toxicity Evaluation of Milk Thistle Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A41673
Summary Data
Genetic Toxicity Evaluation of Milk Thistle Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A42260
Summary Data
Genetic Toxicity Evaluation of Milk Thistle Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A44499
Summary Data
Genetic Toxicity Evaluation of Milk Thistle Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A78884
Summary Data
Genetic Toxicity Evaluation of Milk Thistle Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G99059
Summary Data