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Melphalan (148-82-3)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6020804


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Melphalan (148-82-3).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Melphalan (148-82-3).
Micronucleus - Mice
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Weakly Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Melphalan (148-82-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Melphalan (148-82-3).
Bacterial Mutagenicity
View
  • Positive

Citation Information


NTP. Melphalan (148-82-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342
Shelby, M.D., Gulati, D.K., Tice, R.R., and Wojciechowski, J.P. Results of tests for micronuclei and chromosomal aberrations in mouse bone marrow cells with the human carcinogens 4-aminobiphenyl, treosulphan, and melphalan. Environ. Molec. Mutagen. Vol. 13 (1989) 339-342

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C97011M) of Transgenic Model (Melphalan) (148-82-3) in FVB/N Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97011C) of Melphalan (148-82-3) in FVB/N Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011C) of Transgenic Model (Melphalan) (148-82-3) in FVB/N Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97011D) of Melphalan (148-82-3) in FVB/N Mice Exposed via Gavage. NTP Special Study
26-Week Evaluation of the Toxicity (C97011D) of Transgenic Model (Melphalan) (148-82-3) in FVB/N Mice Exposed via Gavage
4-Week Evaluation of the Toxicity (C97011M) of Melphalan (148-82-3) in FVB/N Mice Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C97011C) of Transgenic Model (Melphalan) (148-82-3) in Tg.AC Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97011C) of Transgenic Model (Melphalan) (148-82-3) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011D) of Melphalan (148-82-3) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Melphalan (148-82-3) in Micronucleus Study 141321 in B6C3F1 Mice
Genetic Toxicity Evaluation of Melphalan (148-82-3) in Micronucleus Study A19873 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Melphalan (148-82-3) in Micronucleus Study A52832 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Melphalan (148-82-3) in Micronucleus Study A84411 in FVB/N Mice
Genetic Toxicity Evaluation of Melphalan (148-82-3) in Micronucleus Study A93719 in FVB/N Mice
Genetic Toxicity Evaluation of Melphalan in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 331518
Summary Data