COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Salicylazosulfapyridine (599-79-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0021256


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Some Evidence, Male, Rats
View
  • Some Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Salicylazosulfapyridine (599-79-1).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Salicylazosulfapyridine (599-79-1).
Micronucleus - Mice
View
  • Male: Positive (Nonstandard Protocol)
    Female: Positive
View
  • Male: Not a Valid Test
View
  • Male: Negative
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Salicylazosulfapyridine (599-79-1).
Micronucleus - Rats
View
  • Male: Equivocal
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Salicylazosulfapyridine (599-79-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Salicylazosulfapyridine (599-79-1).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Salicylazosulfapyridine (599-79-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-457 Toxicology and Carcinogenesis Studies of Salicylazosulfapyridine (CASRN 599-79-1) in F344 Rats and B6C3F1 Mice (Gavage Studies)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Witt, K.L., Knapton, A., Wehr, C.M., Hook, G.J., Mirsalis, J., Shelby, M.D., and MacGregor, J.T. Micronucleated Erythrocyte Frequency in Peripheral Blood of B6C3F1 Mice from Short-Term, Prechronic, and Chronic Studies of the NTP Carcinogenesis Bioassay Program. Environ. Molec. Mutagen. Vol. 36 (2000) 163-194
Bishop, J.B., Witt, K.L., Gulati, D.K., and MacGregor, J.T. Evaluation of the mutagenicity of the Anti-inflammatory drug salicylazosulfapyridine (SASP). Mutagenesis Vol. 5 (1990) 549-554
Bishop, J.B., Witt, K.L., Gulati, D.K., and MacGregor, J.T. Evaluation of the mutagenicity of the Anti-inflammatory drug salicylazosulfapyridine (SASP). Mutagenesis Vol. 5 (1990) 549-554
Bishop, J.B., Witt, K.L., Gulati, D.K., and MacGregor, J.T. Evaluation of the mutagenicity of the Anti-inflammatory drug salicylazosulfapyridine (SASP). Mutagenesis Vol. 5 (1990) 549-554

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C61552) of Salicylazosulfapyridine (599-79-1) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C61552) of Salicylazosulfapyridine (599-79-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61552B) of Salicylazosulfapyridine (599-79-1) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61552B) of Salicylazosulfapyridine (599-79-1) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61552B) of Salicylazosulfapyridine (599-79-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C61552B) of Salicylazosulfapyridine (599-79-1) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Salicylazosulfapyridine (599-79-1) in Micronucleus Study 107236 in F344 Rats
Genetic Toxicity Evaluation of Salicylazosulfapyridine (599-79-1) in Micronucleus Study 459882 in B6C3F1 Mice
Genetic Toxicity Evaluation of Salicylazosulfapyridine (599-79-1) in Micronucleus Study 724355 in B6C3F1 Mice
Genetic Toxicity Evaluation of Salicylazosulfapyridine (599-79-1) in Micronucleus Study A66124 in B6C3F1 Mice
Genetic Toxicity Evaluation of Salicylazosulfapyridine (599-79-1) in Micronucleus Study A72306 in B6C3F1 Mice
Genetic Toxicity Evaluation of Salicylazosulfapyridine (599-79-1) in Micronucleus Study A93691 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Salicylazosulfapyridine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 031562
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (S0312) of Salicylazosulfapyridine (599-79-1) and Sulfapyridine (144-83-2) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection
Data - Sulfapyridine
Data - Salicylazosulfapyridine