Di(2-ethylhexyl)phthalate (117-81-7)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020607
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
Rodent Cytogenetics |
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CA |
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Micronucleus - Mice |
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Mammalian Cell Mutagenicity |
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Mammalian Cell Cytogenetics | |
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CA | SCE |
In Vivo Alkaline Comet Assay - Rats |
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Drosophila Germ Cell Mutagenicity |
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SLRL |
Bacterial Mutagenicity |
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Publications
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Study Data
Toxicity and Carcinogenicity Studies
5-day study (C10188D) of Di(2-ethylhexyl)Phthalate (117-81-7) delivered via Gavage in HSD Rat
Study Tables
- I01 - Animal Removal Summary (31 kB)
- I03 - Growth Curve (330 kB)
- I03C - Growth Curve (339 kB)
- I04 -Mean Body Weight Summary (65 kB)
- I04G - Mean Body Weight Gain (53 kB)
- I05 - Clinical Observations Summary (40 kB)
- PA06 - Organ Weights Summary (56 kB)
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Female B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C10188) of Di(2-ethylhexyl) Phthalate (117-81-7 ) in Harlan Sprague-Dawley Rats Exposed Via Dosed feed
Study Tables
- E01 - Animal Removal Summary By Treatment Group (13 kB)
- E02 - Animals Removed from Experiment (172 kB)
- E03 - Growth Curve - litter-based (68 kB)
- E04 - Mean Body Weight and Survival Table - litter based (20 kB)
- E05 - Clinical Observations Summary (32 kB)
- E08 - Feed and Compound Consumption Table (42 kB)
- Gestational Body Weights (22 kB)
- Gestational Food Consumption (18 kB)
- Gestational and Lactational Chemical Consumption (20 kB)
- Lactational Body Weights (21 kB)
- Lactational Food Consumption (18 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (74 kB)
- P04 - Neoplasms by Individual Animal (816 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (56 kB)
- P08 - Statistical Analysis of Primary Tumors (1 mB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Litter based (2 mB)
- P11 - Statistical Analysis of Survival Data (29 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (756 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (76 kB)
- P22 - Cause of Death Summary (20 kB)
- P40 - Survival Curves (495 kB)
- PA46Rs - Summary of Gross Pathology with Litter Incidence (327 kB)
- PA48 - Summary of Tissue Concentration (38 kB)
- PND 1 Litter Data (24 kB)
- PND 4 Live Litter Size and Survival (116 kB)
- Pup Body Weights (22 kB)
- R02 - Reproductive Performance Summary (41 kB)
- R23 - Gubernaculum Length Summary (56 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (513 kB)
- Female Individual Animal Body Weight Data All Animals - Gestation (64 kB)
- Female Individual Animal Body Weight Data All Animals - Lactation (38 kB)
- Female Individual Animal Clinical Observations (251 kB)
- Female Individual Animal Neoplastic Pathology Data (137 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Survival - Gestation (37 kB)
- Female Individual Animal Survival -Lactation (24 kB)
- Female Individual Animal Survival Data (42 kB)
- Female Individual Animal Terminal Body Weight - Gestation (63 kB)
- Female Individual Animal Terminal Body Weight - Lactation (43 kB)
- Female Individual Animal Terminal Body Weight Data (71 kB)
- Individual Animal Clinical Observations Data (9 kB)
- Individual Animal DamID and PupID Data (22 kB)
- Individual Animal Reproductive Performance Data (13 kB)
- Individual Animal Tissue Concentration Data (7 kB)
- Individual Pup Census and Litter Weight by Sex Data (26 kB)
- Male Individual Animal Body Weight Data All Animals (511 kB)
- Male Individual Animal Clinical Observations (195 kB)
- Male Individual Animal Neoplastic Pathology Data (146 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Survival Data (41 kB)
- Male Individual Animal Terminal Body Weight Data (71 kB)
- Urogenital Observation Data and Summaries (352 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C10188B) of Di(2-ethylhexyl) Phthalate (117-81-7 ) in Harlan Sprague-Dawley Rats Exposed Via Dosed Feed
Study Tables
- E01 - Animal Removal Summary By Treatment Group (13 kB)
- E02 - Animals Removed from Experiment (152 kB)
- E03 - Growth Curves (491 kB)
- E04 - Mean Body Weights and Survival Table (20 kB)
- E05 - Clinical Observations Summary (32 kB)
- E08 - Feed and Compound Consumption Table (42 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (75 kB)
- P04 - Neoplasms by Individual Animal (870 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (54 kB)
- P08 - Statistical Analysis of Primary Tumors (243 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions
- P10 - Statistical Analysis of Non-Neoplastic Lesions - Litter based (489 kB)
- P11 - Statistical Analysis of Survival Data (28 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (754 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (78 kB)
- P22 - Cause of Death Summary (17 kB)
- P40 - Survival Curves (502 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data All Animals (491 kB)
- Female Individual Animal Clinical Observations (234 kB)
- Female Individual Animal Neoplastic Pathology Data (167 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Survival Data (42 kB)
- Female Individual Animal Terminal Body Weight Data (71 kB)
- Male Individual Animal Body Weight Data All Animals (485 kB)
- Male Individual Animal Clinical Observations (148 kB)
- Male Individual Animal Neoplastic Pathology Data (149 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Survival Data (41 kB)
- Male Individual Animal Terminal Body Weight Data (71 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of DEHP (117-81-7) in DNA Damage Study G10188 in Sprague-Dawley Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A04384 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A15851 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A15927 in B6C3F1 Mice
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 064176
Summary Data
- G06 - Ames Summary Data (134 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 195347
Summary Data
- G06 - Ames Summary Data (144 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 483211
Summary Data
- G06 - Ames Summary Data (128 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 894518
Summary Data
- G06 - Ames Summary Data (149 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 960176
Summary Data
- G06 - Ames Summary Data (136 KB)
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 965968
Summary Data
- G06 - Ames Summary Data (62 KB)
Other NTP Studies
ADME/TK Evaluation (S0054) of Di(2-ethylhexyl) phthalate (117-81-7) in F344 Rats Exposed via Dermal Application
Prenatal Developmental Toxicity Study (TER84063) of Di(2-ethylhexyl) Phthalate (117-81-7) in F344/N Rats Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (22 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (24 kB)
- Fetal Data: All Malformations (462 kB)
- Fetal Data: All Variations (462 kB)
- Fetal Data: Fetal Body Weights (457 kB)
- Live Litter: All Litter (459 kB)
- Live Litter: Live Litter (463 kB)
Prenatal Developmental Toxicity Study (TER84064) of Di(2-ethylhexyl) Phthalate (117-81-7) in Swiss CD-1 Mice Exposed via Dosed Feed
Individual and Summary Data
- Dam Data: Dam Body Weights (23 kB)
- Dam Data: Dam Pregnancy Status (3 kB)
- Dam Data: Organ Weights (25 kB)
- Fetal Data: All Malformations (669 kB)
- Fetal Data: All Variations (669 kB)
- Fetal Data: Fetal Body Weights (664 kB)
- Live Litter: All Litter (666 kB)
- Live Litter: Live Litter (669 kB)
Screen for Developmental Toxicity in Zebrafish- Study 1
Results
- Zebrafish 2,3,7,8-Tetrachlorodibenzo-p-dioxin CASRN 1746-01-6 (28 kB)
- Zebrafish 1-Ethyl-3-methylimidazolium diethylphosphate CASRN 848641-69-0 (21 kB)
- Zebrafish 1-Methyl-4-phenylpyridinium iodide CASRN 36913-39-0 (21 kB)
- Zebrafish 2,2',4,4',5,5'-Hexabromodiphenyl ether (BDE-153) CASRN 68631-49-2 (21 kB)
- Zebrafish 2,2',4,4',5-Pentabromodiphenyl ether (BDE-99) CASRN 60348-60-9 (22 kB)
- Zebrafish 2,2',4,4'-Tetrabromodiphenyl ether CASRN 5436-43-1 (28 kB)
- Zebrafish 2-Ethylhexyl diphenyl phosphate (EHDP) CASRN 1241-94-7 (28 kB)
- Zebrafish 2-Ethylhexyl-2,3,4,5-tetrabromobenzoate (TBB) CASRN 183658-27-7 (21 kB)
- Zebrafish 2-Methoxyethanol CASRN 109-86-4 (22 kB)
- Zebrafish 3,3'-Iminodipropionitrile CASRN 111-94-4 (22 kB)
- Zebrafish 3,3’,5,5’-Tetrabromobisphenol A CASRN 79-94-7 (28 kB)
- Zebrafish 4-H-Cyclopenta(d,e,f)phenanthrene CASRN 203-64-5 (28 kB)
- Zebrafish 5-Fluorouracil CASRN 51-21-8 (21 kB)
- Zebrafish 5-nitro-2-furaldehyde semicarbazone CASRN 59-87-0 (23 kB)
- Zebrafish 6-Hydroxydopamine hydrochloride CASRN 28094-15-7 (21 kB)
- Zebrafish 6-Propyl-2-thiouracil CASRN 51-52-5 (21 kB)
- Zebrafish Acenaphthene CASRN 83-32-9 (28 kB)
- Zebrafish Acenaphthylene CASRN 208-96-8 (28 kB)
- Zebrafish Acetaminophen (4-hydroxyacetanilide) CASRN 103-90-2 (22 kB)
- Zebrafish Acetic acid, manganese (2+) salt CASRN 638-38-0 (22 kB)
- Zebrafish Acetylsalicylic acid CASRN 50-78-2 (21 kB)
- Zebrafish Acrylamide CASRN 79-06-1 (22 kB)
- Zebrafish Aldicarb CASRN 116-06-3 (28 kB)
- Zebrafish Amoxicillin CASRN 26787-78-0 (21 kB)
- Zebrafish Anthracene CASRN 120-12-7 (21 kB)
- Zebrafish Auramine O CASRN 2465-27-2 (28 kB)
- Zebrafish Benz(a)anthracene CASRN 56-55-3 (27 kB)
- Zebrafish Benzo(a)pyrene CASRN 50-32-8 (27 kB)
- Zebrafish Benzo(b)fluoranthene CASRN 205-99-2 (28 kB)
- Zebrafish Benzo(e)pyrene CASRN 192-97-2 (28 kB)
- Zebrafish Benzo(k)fluoranthene CASRN 207-08-9 (27 kB)
- Zebrafish Benzog,h,i perylene CASRN 191-24-2 (21 kB)
- Zebrafish Berberine chloride CASRN 633-65-8 (21 kB)
- Zebrafish Bis(2-ethylhexyl) 3,4,5,6- tetrabromophthalate (TBPH) CASRN 26040-51-7 (21 kB)
- Zebrafish Bis(tributyltin)oxide CASRN 56-35-9 (28 kB)
- Zebrafish Bisphenol A CASRN 80-05-7 (27 kB)
- Zebrafish Bisphenol AF CASRN 1478-61-1 (28 kB)
- Zebrafish Bisphenol S CASRN 80-09-1 (21 kB)
- Zebrafish Captan CASRN 133-06-2 (27 kB)
- Zebrafish Carbamic acid, butyl-, 3-iodo-2-propynyl ester CASRN 55406-53-6 (28 kB)
- Zebrafish Carbaryl CASRN 63-25-2 (27 kB)
- Zebrafish Chlorpyrifos (Dursban) CASRN 2921-88-2 (27 kB)
- Zebrafish Chrysene CASRN 218-01-9 (21 kB)
- Zebrafish Colchicine CASRN 64-86-8 (27 kB)
- Zebrafish D-Glucitol CASRN 50-70-4 (21 kB)
- Zebrafish Deltamethrin CASRN 52918-63-5 (45 kB)
- Zebrafish Di(2-ethylhexyl) phthalate CASRN 117-81-7 (22 kB)
- Zebrafish Diazepam CASRN 439-14-5 (28 kB)
- Zebrafish Dibenz a,c anthracene CASRN 215-58-7 (21 kB)
- Zebrafish Dibenz(a,h)anthracene CASRN 53-70-3 (27 kB)
- Zebrafish Dichlorodiphenyltrichloroethane (DDT) CASRN 50-29-3 (28 kB)
- Zebrafish Dieldrin CASRN 60-57-1 (27 kB)
- Zebrafish Diethylstilbestrol CASRN 56-53-1 (28 kB)
- Zebrafish Estradiol CASRN 50-28-2 (28 kB)
- Zebrafish Firemaster 550 CASRN 860302-33-6 (28 kB)
- Zebrafish Fluorene CASRN 86-73-7 (28 kB)
- Zebrafish Heptachlor CASRN 76-44-8 (28 kB)
- Zebrafish Hexachlorophene CASRN 70-30-4 (28 kB)
- Zebrafish Hydroxyurea CASRN 127-07-1 (21 kB)
- Zebrafish Isodecyl diphenyl phosphate CASRN 29761-21-5 (27 kB)
- Zebrafish L-Ascorbic acid CASRN 50-81-7 (21 kB)
- Zebrafish Lead (II) acetate trihydrate CASRN 6080-56-4 (27 kB)
- Zebrafish Lindane CASRN 58-89-9 (27 kB)
- Zebrafish MPEP CASRN 95737-68-1 (29 kB)
- Zebrafish Manganese, tricarbonyl (1,2,3,4,5-.eta.)-1-methyl-2,4-cyclopentadien-1-yl- CASRN 12108-13-3 (21 kB)
- Zebrafish Methyl mercuric (II) chloride CASRN 115-09-3 (46 kB)
- Zebrafish Naphthalene CASRN 91-20-3 (27 kB)
- Zebrafish Parathion CASRN 56-38-2 (28 kB)
- Zebrafish Permethrin CASRN 52645-53-1 (27 kB)
- Zebrafish Phenanthrene CASRN 85-01-8 (28 kB)
- Zebrafish Phenobarbital CASRN 50-06-6 (21 kB)
- Zebrafish Phenobarbital sodium salt CASRN 57-30-7 (27 kB)
- Zebrafish Phenol, isopropylated, phosphate (3 to1) CASRN 68937-41-7 (28 kB)
- Zebrafish Pyrene CASRN 129-00-0 (27 kB)
- Zebrafish Rotenone CASRN 83-79-4 (28 kB)
- Zebrafish Saccharin Sodium Salt hydrate CASRN 82385-42-0 (33 kB)
- Zebrafish Tebuconazole CASRN 107534-96-3 (28 kB)
- Zebrafish Tetraethylthiuram disulfide CASRN 97-77-8 (28 kB)
- Zebrafish Thalidomide CASRN 50-35-1 (27 kB)
- Zebrafish Toluene CASRN 108-88-3 (21 kB)
- Zebrafish Tricresyl phosphate CASRN 1330-78-5 (28 kB)
- Zebrafish Triphenyl phosphate CASRN 115-86-6 (46 kB)
- Zebrafish Tris(2-Chloroethyl) Phosphate CASRN 115-96-8 (21 kB)
- Zebrafish Valinomycin CASRN 2001-95-8 (29 kB)
- Zebrafish Valproic acid sodium salt CASRN 1069-66-5 (27 kB)
- Zebrafish n-Hexane CASRN 110-54-3 (27 kB)
- Zebrafish tert-Butylphenyl diphenyl phosphate CASRN 56803-37-3 (29 kB)
- Zebrafish tris(Chloropropyl) phosphate, TCPP CASRN 13674-84-5 (27 kB)