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Di(2-ethylhexyl)phthalate (117-81-7)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID5020607


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Positive, Male, Rats
View
  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
Rodent Cytogenetics
CA
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
Micronucleus - Mice
View
  • Female: Equivocal
View
  • Male: Negative
    Female: Negative
View
  • Male: Equivocal
    Female: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Rats study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
In Vivo Alkaline Comet Assay - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Di(2-ethylhexyl)phthalate (117-81-7).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative
View
  • Negative

Citation Information


NTP. Di(2-ethylhexyl)phthalate (117-81-7). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-217 Carcinogenesis Bioassay of Di(2-ethylhexyl)phthalate (CASRN 117-81-7) in F344 Rats and B6C3F1 Mice (Feed Studies)
TR-601 Toxicology and Carcinogenesis Studies of Di(2‑ethylhexyl) Phthalate Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Zeiger, E., Haworth, S., Mortelmans, K., and Speck, W. Mutagenicity testing of Di(2-ethylhexyl)phthalate and related chemicals in Salmonella Environ. Mutagen. Vol. 7 (1985) 213-232
Teratologic Evaluation of Diethylhexyl Phthalate (CASRN 117-81-7) in Fischer 344 Rats
Teratologic Evaluation of Diethylhexyl Phthalate (CASRN 117-81-7) in CD-1 Mice
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Di(2-ethylhexyl) Phthalate (117-81-7) in Female B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C10188) of Di(2-ethylhexyl) Phthalate (117-81-7 ) in Harlan Sprague-Dawley Rats Exposed Via Dosed feed
Study Tables
Individual Animal Data
Evaluation of the Chronic Toxicity and Carcinogenicity (C10188B) of Di(2-ethylhexyl) Phthalate (117-81-7 ) in Harlan Sprague-Dawley Rats Exposed Via Dosed Feed
Study Tables
Individual Animal Data

Genetic Toxicology Studies


Genetic Toxicity Evaluation of DEHP (117-81-7) in DNA Damage Study G10188 in Sprague-Dawley Rats
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A04384 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A15851 in Tg.AC (FVB/N) Mice
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate (117-81-7) in Micronucleus Study A15927 in B6C3F1 Mice
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 064176
Summary Data
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 195347
Summary Data
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 483211
Summary Data
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 894518
Summary Data
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 960176
Summary Data
Genetic Toxicity Evaluation of Di(2-ethylhexyl) Phthalate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 965968
Summary Data

Other NTP Studies


ADME/TK Evaluation (S0054) of Di(2-ethylhexyl) phthalate (117-81-7) in F344 Rats Exposed via Dermal Application
Prenatal Developmental Toxicity Study (TER84063) of Di(2-ethylhexyl) Phthalate (117-81-7) in F344/N Rats Exposed via Dosed Feed
Prenatal Developmental Toxicity Study (TER84064) of Di(2-ethylhexyl) Phthalate (117-81-7) in Swiss CD-1 Mice Exposed via Dosed Feed
Screen for Developmental Toxicity in Zebrafish- Study 1
Results