NIEHS Report 08: NIEHS Report on the In Vivo Repeat Dose Biological Potency Study of 1,1,2,2-Tetrahydroperfluoro-1-dodecanol (CASRN 865-86-1) in Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats (Gavage Studies)
Short-Term
Apical Benchmark Dose Analysis
- BMD, NOEL and LOEL Summary for Apical Endpoints (16 KB)
- BMD Model Recommendation Selection Rules (14 KB)
- BMDs code package (26 MB)
- Clinical Chemistry Summary (17 KB)
- Female BMD Apical Endpoints Model Fits (2 MB)
- Female Model Parameters (1 MB)
- Hematology Summary (16 KB)
- Hormone and Enzymes Summary (15 KB)
- Male BMD Apical Endpoints Model Fits (1 MB)
- Male Model Parameters (678 KB)
- Mean Body Weight Summary (15 KB)
- Organ Weights Summary (16 KB)
- Read Me (14 KB)
Genomic Benchmark Dose Analysis
- Animal and Fastaq Metadata (254 KB)
- BMDExpress Expression Data_Kidney_Female (1 MB)
- BMDExpress Expression Data_Kidney_Male (1 MB)
- BMDExpress Expression Data_Liver_Female (1 MB)
- BMDExpress Expression Data_Liver_Male (1 MB)
- BMDExpress GO Biological Process Deduplicated BMD Results_Kidney_Female (516 KB)
- BMDExpress GO Biological Process Deduplicated BMD Results_Kidney_Male (844 KB)
- BMDExpress GO Biological Process Deduplicated BMD Results_Liver_Female (2 MB)
- BMDExpress GO Biological Process Deduplicated BMD Results_Liver_Male (4 MB)
- BMDExpress Individual Gene BMD Results_Kidney_Female (16 KB)
- BMDExpress Individual Gene BMD Results_Kidney_Male (28 KB)
- BMDExpress Individual Gene BMD Results_Liver_Female (58 KB)
- BMDExpress Individual Gene BMD Results_Liver_Male (99 KB)
- BMDExpress Prefilter Results_ Kidney _Female (19 KB)
- BMDExpress Prefilter Results_ Kidney _Male (30 KB)
- BMDExpress Prefilter Results_ Liver _Female (66 KB)
- BMDExpress Prefilter Results_ Liver _Male (115 KB)
- BMDExpress Project File (bm2 format) (39 MB)
- BMDExpress Project File (JSON format) (22 MB)
- BMDExpress Software (63 MB)
- GO Biological Process BMD Analysis Results (3 MB)
- Individual Gene BMD Analysis Results File (260 KB)
- Kidney Principal Components Analysis Files (2 MB)
- Liver Principal Components Analysis Files (2 MB)
- Top 10 Genes Ranked by Potency of Perturbation_Kidney (24 KB)
- Top 10 Genes Ranked by Potency of Perturbation_Liver (22 KB)
- Top 10 GO Biological Process Gene Sets_Kidney (19 KB)
- Top 10 GO Biological Process Gene Sets_Liver (19 KB)
Study Tables
- I04 – Mean_Body_Weight_Summary (136 KB)
- I05 – Clinical_Observations_Summary (76 KB)
- PA06 – Organ_Weights_Summary (107 KB)
- PA41 – Clinical_Chemistry_Summary (354 KB)
- PA43 - Hematology Summary (429 KB)
- PA48 - Summary of Tissue Concentration (32 KB)
- R07 – Hormone_Summary (78 KB)
Individual Animal Data
- Individual Animal Body Weight Data (12 KB)
- Individual Animal Clinical Chemistry Data (16 KB)
- Individual Animal Clinical Observations Data (26 KB)
- Individual Animal Hematology Data (17 KB)
- Individual Animal Hormone Data (9 KB)
- Individual Animal Organ Weight Data (10 KB)
- Individual Animal Tissue Concentration Data (6 KB)