U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

TR-571: Kava kava extract (9000-38-8)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to TR-571: Kava kava extract (9000-38-8).
Micronucleus - Mice
View
  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to TR-571: Kava kava extract (9000-38-8).
Bacterial Mutagenicity
View
  • Negative
View
  • Negative

Citation Information


NTP. TR-571: Kava kava extract (9000-38-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-571 Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Kava Kava Extract (9000-38-8) in Micronucleus Study A53705 in B6C3F1 Mice
Genetic Toxicity Evaluation of Kava Kava Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A00186
Summary Data
Genetic Toxicity Evaluation of Kava Kava Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A88186
Summary Data