TR-571: Kava kava extract (9000-38-8)
Study Results
Chronic Bioassay Level of Evidence
| Rats | |
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| Mice | |
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Genetic Toxicology
| Micronucleus - Mice |
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| Bacterial Mutagenicity |
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Publications
TR-571
Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (526 kB)
- E04 - Mean Body Weights and Survival Table (20 kB)
- E05 - Clinical Observations Summary (23 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (56 kB)
- P04 - Neoplasms by Individual Animal (690 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (49 kB)
- P08 - Statistical Analysis of Primary Tumors (222 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (836 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (456 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (611 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (58 kB)
- P40 - Survival Curves (525 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (371 kB)
- Female Individual Animal Clinical Observations (171 kB)
- Female Individual Animal Neoplastic Pathology Data (139 kB)
- Female Individual Animal Non Neoplastic Pathology Data (776 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (327 kB)
- Male Individual Animal Clinical Observations (123 kB)
- Male Individual Animal Neoplastic Pathology Data (189 kB)
- Male Individual Animal Non Neoplastic Pathology Data (875 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (538 kB)
- E04 - Mean Body Weights and Survival Table (20 kB)
- E05 - Clinical Observations Summary (22 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (50 kB)
- P04 - Neoplasms by Individual Animal (411 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (45 kB)
- P08 - Statistical Analysis of Primary Tumors (204 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (472 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (441 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (393 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (54 kB)
- P40 - Survival Curves (524 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (345 kB)
- Female Individual Animal Clinical Observations (40 kB)
- Female Individual Animal Neoplastic Pathology Data (104 kB)
- Female Individual Animal Non Neoplastic Pathology Data (753 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (391 kB)
- Male Individual Animal Clinical Observations (48 kB)
- Male Individual Animal Neoplastic Pathology Data (152 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Kava Kava Extract (9000-38-8) in Micronucleus Study A53705 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Kava Kava Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A00186
Summary Data
- G06 - Ames Summary Data (157 KB)
Genetic Toxicity Evaluation of Kava Kava Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A88186
Summary Data
- G06 - Ames Summary Data (74 KB)