Kava kava extract (9000-38-8)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID901018742
Study Results
Chronic Bioassay Level of Evidence
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Genetic Toxicology
| Micronucleus - Mice |
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| Bacterial Mutagenicity |
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Publications
TR-571
Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Reduced Disc Shedding and Phagocytosis of Photoreceptor Outer Segment Contributes to Kava Kava Extract-induced Retinal Degeneration in F344/N Rats
Haruhiro Yamashita, Mark J. Hoenerhoff, Keith R. Shockley, Shyamal D. Peddada, Kevin E. Gerrish, Deloris Sutton, Connie A. Cummings, Yu Wang, Julie F. Foley, Mamta Behl, Suramya Waidyanatha, Robert C. Sills, and Arun R. Pandiri.
Toxicologic Pathology (2018) DOI: https://doi.org/10.1177/0192623318778796 PMID: 29806545
Toxicologic Pathology (2018) DOI: https://doi.org/10.1177/0192623318778796 PMID: 29806545
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344 Rats Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344 Rats Exposed via Gavage. NTP Special Study
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344 Rats Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E08 - Feed, Water, And Compound Consumption Table
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P10 - Statistical Analysis Of Non-Neoplastic Lesions
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
Evaluation of the Chronic Toxicity and Carcinogenicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (526 kB)
- E04 - Mean Body Weights and Survival Table (20 kB)
- E05 - Clinical Observations Summary (23 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (56 kB)
- P04 - Neoplasms by Individual Animal (690 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (49 kB)
- P08 - Statistical Analysis of Primary Tumors (222 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (836 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (456 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (611 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (58 kB)
- P40 - Survival Curves (525 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (371 kB)
- Female Individual Animal Clinical Observations (171 kB)
- Female Individual Animal Neoplastic Pathology Data (139 kB)
- Female Individual Animal Non Neoplastic Pathology Data (776 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (327 kB)
- Male Individual Animal Clinical Observations (123 kB)
- Male Individual Animal Neoplastic Pathology Data (189 kB)
- Male Individual Animal Non Neoplastic Pathology Data (875 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (538 kB)
- E04 - Mean Body Weights and Survival Table (20 kB)
- E05 - Clinical Observations Summary (22 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (50 kB)
- P04 - Neoplasms by Individual Animal (411 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (45 kB)
- P08 - Statistical Analysis of Primary Tumors (204 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (472 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (441 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (393 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (54 kB)
- P40 - Survival Curves (524 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (345 kB)
- Female Individual Animal Clinical Observations (40 kB)
- Female Individual Animal Neoplastic Pathology Data (104 kB)
- Female Individual Animal Non Neoplastic Pathology Data (753 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (391 kB)
- Male Individual Animal Clinical Observations (48 kB)
- Male Individual Animal Neoplastic Pathology Data (152 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (34 kB)
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
Special Evaluation of the Toxicity (C20007) of Kava Kava Extract (9000-38-8) in B6C3F1 Mice Exposed via Gavage
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Kava Kava Extract (9000-38-8) in Micronucleus Study A53705 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Kava Kava Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A00186
Summary Data
- G06 - Ames Summary Data (157 KB)
Genetic Toxicity Evaluation of Kava Kava Extract in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A88186
Summary Data
- G06 - Ames Summary Data (74 KB)